Research: Concussions, Plantar Fasciitis, Primary Mitochondrial Diseases, & Methylene Blue & Toluidine Blue Combats Cancer

This week we are going to dig into some interesting research I've been compiling the last several months (and I have plenty more where this came from!). We will cover an array of our favorite topics in red light therapy, mitochondria and methylene blue.

We will first look at a piece of research that discusses primary mitochondrial diseases (PMDs); however, the article is directed towards physicians and how they can start to recognize patterns and red flags associated with various PMDs (i.e., mitochondrial dysfunction). To me this is extremely exciting in the sense that this type of mitochondrial information is (slowly but surely) permeating its way into the allopathic world. It can't happen fast enough!

The second article looks at methylene blue and a new, yet quite similar synthetic dye salt, blue compound called toluidine blue. The study looks at how when used together, they have a synergistic effect against oral squamous cell carcinoma. I need to know more about toluidine blue!

The third article looks at the effect of transcranial photobiomodulation on concussions. This study is a perfect example of a "non-result" not necessarily being a bad thing or that is should be taken at face value. I will discuss why.

The last, and likely most relevant, study I review is on red light therapy's impact on reducing pain and improving function with plantar fasciitis (PF). I've personally never dealt with PF, but I have treated it countless times as a physical therapist and know many other people that have dealt with it -- long story short, it is not fun in the slightest and is incredibly easy for it to become a chronic and/or recurring issue. Red light therapy certainly has a role to play with PF. And, based on my experience, cupping may be one of the BEST modalities in the fight against PF. Did anyone say ReVamp cupping system for combined red light therapy and cupping?

 

As always, enjoy the information and light up your health!

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Key points:

 

Introduction and Content Teaser (00:00:16 - 00:01:04:29)

• Dr. Mike's welcome and reflections.
• Teaser for red light therapy, mitochondrial health, and more.

BioLight's Evolution (00:01:04:29 - 00:04:05:09)

• Revamped cupping system introduction.
• Upcoming research coverage.
• BioLight's future and seamless integration.

Vision and Innovation (00:04:05:09 - 00:06:45:01)

• Vision for 2024 and beyond.
• Examples of integrating red light therapy.
• BioLight's new direction and upcoming products.

Mitochondrial Health Focus (00:06:45:04 - 00:08:06:22)

• Integration of methylene blue.
• BioLight as a mitochondrial health company.

Primary Mitochondrial Diseases (00:08:06:24 - 00:14:14:25)

• Introduction to the research article.
• Red flags and manifestations across body systems.
• Conclusion and article promotion.

Mitochondrial Oxidative Phosphorylation (00:18:25:17 - 00:19:32:25)

• Focus on genetically determined impairment.
• Reiteration of manifestations and red flags.

Photodynamic Therapy with Methylene Blue (00:21:07:08 - 00:28:03:14)

• Introduction to the second article.
• Investigation and synergistic effects.
• Toluidine blue's potential and further exploration.

Red Light Therapy and Concussion

• Introduction to red light therapy for concussion (00:28:03 - 00:28:44)
• Emphasis on mitochondria's role in brain health.

Mitochondrial Dense Tissue (00:28:44 - 00:29:15)

• Significance of mitochondria in the brain.
• Teaser for transcranial photobiomodulation article.

Clinical Trial Article (00:29:15 - 00:29:55)

• Overview of a randomized clinical trial on photobiomodulation.

Background on Transcranial Photobiomodulation (00:29:55 - 00:30:27)

• Literature on benefits for post-concussion recovery.

Methods and Outcome Measures (00:30:27 - 00:31:16)

• Description of the study methods and primary outcome measure.

Participant Demographics and Sessions (00:31:16 - 00:32:22)

• Details on participants and session frequency.

Results and Conclusion (00:32:22 - 00:33:37)

• Presentation of results and conclusion.

Research Limitations (00:33:37 - 00:34:40)

• Reflection on study limitations and importance of details.

Negative Results and Quality (00:34:40 - 00:36:05)

• Interpretation of negative results and critique of research quality.

Final Thoughts (00:36:05 - 00:37:04)

• Reminder that negative results don't dismiss potential benefits.

Plantar Fasciitis and Photobiomodulation Therapy

• Introduction to Plantar Fasciitis Article (00:39:14 - 00:39:54)
• Teaser for an article on Photobiomodulation Therapy for plantar fasciitis.

Cupping for Plantar Fasciitis (00:39:55 - 00:41:03)

• Efficacy of cupping for plantar fasciitis.
• Mechanism, benefits, and procedure details.

Cupping Sounds and Pathology (00:41:51 - 00:42:38)

• Discussion on sounds during cupping and their relation to pathology.

Photobiomodulation Article Introduction (00:42:38 - 00:44:10)

• Overview of an article on Photobiomodulation Therapy for plantar fasciitis.

Conservative Treatment Critique (00:44:10 - 00:45:06)

• Critique of conservative treatments for plantar fasciitis.

Corticosteroid Injection Issues (00:45:06 - 00:46:02)

• Caution against corticosteroid injections and their detrimental cycle.

Introduction to Photobiomodulation Therapy (00:46:27 - 00:47:37)

• Introduction to Photobiomodulation Therapy for tendinopathy.

Dosage and Wavelengths (00:47:37 - 00:49:14)

• Enthusiasm for optimized wavelengths and dosing parameters.
• Importance of detailed dosing information.

Near-Infrared for Plantar Fascia (00:49:14 - 00:49:41)

• Advocacy for near-infrared wavelengths for deeper tissue effects.

Study Overview (00:51:19 - 00:53:16)

• Assessment of clinical impact on pain and function.

Photobiomodulation Therapy Protocol (00:53:40 - 00:54:49)

• Details on therapy frequency and duration.

Outcomes and Measurements (00:54:49 - 01:01:01)

• Primary outcomes: pain reduction and functional improvement.

Study Summary and Discussion (01:01:01 - 01:04:34)

• Three main findings and future considerations.

Conclusion and Closing Remarks (01:04:34 - 01:06:45)

• Long-term benefits of standardized therapy.
• Encouragement to share findings and closing remarks.

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Articles referenced in episode:

Red Flags in Primary Mitochondrial Diseases: What Should We Recognize?

 

Photodynamic Therapy with an Association of Methylene Blue and Toluidine Blue Promoted a Synergic Effect against Oral Squamous Cell Carcinoma

 

A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial Evaluating Transcranial Photobiomodulation as Treatment for Concussion

 

Photobiomodulation Therapy Plus Usual Care Is Better than Usual Care Alone for Plantar Fasciitis: A Randomized Controlled Trial

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To learn more about red light therapy and shop for the highest-quality red light therapy products, visit https://www.biolight.shop

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Dr. Mike's #1 recommendations:

• Grounding products: Earthing.com
• EMF-mitigating products: Somavedic
• Blue light blocking glasses: Ra Optics

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